ANTI-D IN RHESUS D POSITIVE PREGNANT MOTHER: A CASE REPORT.
Mohd Nazri HASSAN1,3, Wan Suriana WAN AB RAHMAN2,3, Zefarina ZULKAFLI1,3, Salfarina IBERAHIM1,3, Noor Haslina MOHD NOOR1,3, Rosnah BAHAR1,3, Marne ABDULLAH1,3, Marini RAMLI1,3, Shafini MOHAMED YUSOFF1,3.
1Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.
2School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.
3Hospital Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.
An accurate ABO and Rhesus (Rh) blood group identification, especially D antigen, is essential for pre-transfusion evaluation in pregnancy. This procedure will prevent allo-immunisation or haemolytic disease of foetus and newborn (HDFN). A 32-year-old pregnant lady with an underlying autoimmune disease was noted to have positive antibody screening with the possibility of auto anti-D or anti-LW. Even though the latter antibody is not clinically significant, these two antibodies need to be differentiated. Anti-D may develop in partial D or variant D individual who was mistakenly labeled as Rh (D) positive previously. Unfortunately, it is difficult to establish the blood grouping of patients with an underlying autoimmune process. Therefore, in this case, a molecular study for blood group D was required.
Keywords: Anti-D, Anti-LW, Haemolytic disease of foetus, Molecular, Pregnancy, Rhesus.
Correspondence: Dr Wan Suriana Wan Ab Rahman, Address: School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, E-mail: firstname.lastname@example.org; Phone: +6097675831; Fax: +6097675505.
ORCHID ID: 0000-0003-3878-208x
Brunei Int Med J.2021;17:61-64