ANTI-D IN RHESUS D POSITIVE PREGNANT MOTHER: A CASE REPORT.

Mohd Nazri HASSAN^1,3, Wan Suriana WAN AB RAHMAN^2,3, Zefarina ZULKAFLI^1,3, Salfarina IBERAHIM^1,3, Noor Haslina MOHD NOOR^1,3, Rosnah BAHAR^1,3, Marne ABDULLAH^1,3, Marini RAMLI^1,3, Shafini MOHAMED YUSOFF^1,3. 

¹Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.

²School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.

³Hospital Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan.

ABSTRACT

An accurate ABO and Rhesus (Rh) blood group identification, especially D antigen, is essential for pre-transfusion evaluation in pregnancy. This procedure will prevent allo-immunisation or haemolytic disease of foetus and newborn (HDFN). A 32-year-old pregnant lady with an underlying autoimmune disease was noted to have positive antibody screening with the possibility of auto anti-D or anti-LW. Even though the latter antibody is not clinically significant, these two antibodies need to be differentiated. Anti-D may develop in partial D or variant D individual who was mistakenly labeled as Rh (D) positive previously. Unfortunately, it is difficult to establish the blood grouping of patients with an underlying autoimmune process. Therefore, in this case, a molecular study for blood group D was required.

Keywords: Anti-D,  Anti-LW, Haemolytic disease of foetus, Molecular,  Pregnancy, Rhesus.

Correspondence: Dr Wan Suriana Wan Ab Rahman, Address: School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, E-mail: suriana@usm.my; Phone: +6097675831; Fax: +6097675505.

ORCHID ID: 0000-0003-3878-208x

Brunei Int Med J.2021;17:61-64