DELAYED HYPERSENSITIVITY REACTION SECONDARY TO INTRA-PERITONEAL VANCOMYCIN ADMINISTRATION.

NF ZAKARIA¹, AA PREMILA², A SHAH¹.

¹Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

²Serdang Hospital, 43400 Serdang, Selangor, Malaysia.

ABSTRACT     

Vancomycin has been a drug of choice for infections with a broad range of Gram-positive bacteria. Intraperitoneal (IP) Vancomycin is used to treat methicillin-resistant staphylococcal peritonitis, administered intermittently at 3 to 5 days intervals with trough level monitoring. Numerous adverse drug reactions (ADRs) have been reported with intravenous usage; however, the ADRs are not well known in intraperitoneal administration. We report a case of a delayed hypersensitivity reaction following intraperitoneal vancomycin administration. To date, this is the second case with a similar incidence.

Keywords: Adverse drug reactions, Delayed hypersensitivity, Intraperitoneal, Peritonitis, Vancomycin.

Corresponding author: Dr Nor Fadhlina Zakaria, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Tel:+60123038091; Email: n_fadhlina@upm.edu.my

Brunei Int Med J.2023;19:75-78