Bioactive Glass S53P4 Alternatives to Autologous Bone Graft in the Management of
Large Bone Defects in Children.
Mohd Anuar Ramdhan IBRAHIM1, Faris Indra Prahasta DIDI INDRA*1,
and Muhammad Lutfi ABDUL RASHID2.
1Faculty
of Medicine and Health Sciences, Kota Samarahan, Sarawak.
2Faculty
of Medicine, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Abstract
Traumatic bone defects in children are rare, occurring immediately post-trauma
or secondary to infected non-union. Autologous bone graft is considered the gold
standard and is widely used during the second stage of one of the techniques
known as the induced membrane technique. Bioactive glass S53P4 has been proven
to share similarities with autografts, especially in the formation of new bone.
Its ability to provide local control of infection through antibacterial
properties sets it apart from other types of synthetic bone grafts. We utilized
bioactive glass S53P4 granules alone in the second stage of the induced membrane
technique in a child, resulting in a favorable outcome. The use of bioactive
glass S53P4 granules proves practical in cases where a substantial amount of
bone graft is needed to fill more significant bone defects, thereby avoiding
donor site morbidity.
Keywords: Autografts, Bioactive glass, Bone defects, Bone grafts, S53P4.
Corresponding author:
Faris Indra Prahasta DIDI INDRA,
Faculty of Medicine and Health Sciences, Kota Samarahan, Sarawak.
Brunei Int Med J.2024;20:109-113